Registration Dossier
Registration Dossier
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EC number: 218-542-3 | CAS number: 2177-70-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC = 20 mg/L; OECD guideline 310, toxicity control; GLP
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 20 mg/L
Additional information
One toxicity screening study conducted during theOECD 310 biodegradation test is available for PHMA, which is considered reliable without restriction (Klimisch score 1).
The toxicity of PHMA (99.6% a.i.) to microorganisms was investigated during a ready biodegradation study according to OECD guideline 310 (Headspace Test), adopted 23 March 2006, over a period of 28 days and using predominantly domestic non-adapted activated sludge as inoculum. The biodegradation rate was determined by measurement of carbon dioxide evolution.
Inoculum blank, procedural/functional control with the reference substance Sodium benzoate and toxicity control with reference substance and test substance (20 mg/L test substance) were performed.
For the test item, the 10% level was reached after 1 day. The pass level of 60% was achieved after 5 days, and the biodegradation reached 79% after 28 days. For the functional control the pass level of 60% degradation was reached after 3 days. The biodegradation reached 90% after 28 days.
The biodegradation in the toxicity control reached 87% within 14 days and came to 81% after 28 days. The biodegradation of the reference item was not inhibited by the test item.
Therefore, the test substance was assumed not to inhibit microbial activity at a concentration of 20 mg/L.
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