Registration Dossier
Registration Dossier
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EC number: 203-013-1 | CAS number: 102-20-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic information given, no guideline and no GLP study
Data source
Reference
- Reference Type:
- publication
- Title:
- Some data on the toxic properties of phenylethanol and cinnamic alcohols
- Author:
- Zaitsev A.N.
- Year:
- 1 974
- Bibliographic source:
- Voprosy Pitaniya, 6, 48-53
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The potential of the test item to cause acute oral toxicity was tested in this study with mice.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phenethyl phenylacetate
- EC Number:
- 203-013-1
- EC Name:
- Phenethyl phenylacetate
- Cas Number:
- 102-20-5
- Molecular formula:
- C16H16O2
- IUPAC Name:
- 2-phenylethyl phenylacetate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sunflower oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 45 % solution in sunflower oil (5 mg/kg body weight)
- Doses:
- 20-45 % solution in sunflower oil (2.0-5.0 mL/kg bw)
- No. of animals per sex per dose:
- Groups of 6 white mice
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Statistics:
- LD50 was calculated per Kerber´s method
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 190 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity of the test item was determined. The LD50 with mice was determined to be 3190 mg/kg bw.
- Executive summary:
Groups of 6 white mice (of the same sex) were administered the test material in the form of a 20 - 45% solution in sunflower oil (2.0 - 5.0 mg/kg body weight). The animals were observed for 15 days, and the LD50 was calculated per Kerber's method. No further details were provided. The LD50 value was determined to be 3190 mg/kg bw.
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