Registration Dossier
Registration Dossier
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EC number: 204-234-6 | CAS number: 118-10-5
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity of the read across substance cinchonine hydrochloride to invertebrates:
The read across substance cinchonine hydrochloride was tested in astatic Daphnia magna, Acute Immobilisation Test according to the OECD Guideline 202 for 48 h. Five nominal concentrations between 6.25 and 100 mg/L were used. The EC50 of cinchonine hydrochloride is 79.96 mg/L for Daphnia magna during the test period of 24 h. And the EC50 during the test period of 48 h is 14.25 mg/L. According to this, the EC50 of cinchonine is 11.41 mg/L.
Short-term toxicity of the read across substance quinine sulphate to green algae:
In publication of Moreno-Garrido, 2001 the toxicity of the read across substance quinine sulphate to green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L. We conclude that cinchonine which differs in a methoxy group has a similar EC50 value.
Toxicity of cinchonine to aquatic plants:
In the publication of Wink, 1992 the toxicity of cinchonine to Lemna gibba was determined for 6 days. At a concentration of 0.4% cinchonine does not lead to death or bleaching of Lemna gibba.
Toxicity of cinchonine to microorganisms:
In the study published by Wink, 1998 the bacterial growth inhibition of Bacillus subtilis, Escherichia coli and Serratia marcescens was determined. The IC100 of cinchonine for E. coli is 3 mM (883.2 mg/L) and the IC100 for B. subtilis and S. marcescens is 10 mM (2.94 g/L). Cinchonine has an antibacterial activity.
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