2-hydroxy-1-naphthaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1984 - 1985

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: well performed OECD study woith GLP

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxy-1-naphthaldehyde

EC Number:

211-902-0

EC Name:

2-hydroxy-1-naphthaldehyde

Cas Number:

708-06-5

Molecular formula:

C11H8O2

IUPAC Name:

2-hydroxynaphthalene-1-carbaldehyde

Details on test material:

Purity: 94%

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Strain: Hoe: WISKf (SPF71)
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Weight at study initiation: males: 204+-9.62 g; females: 174,1+-6.62 g
- Fasting period before study: 16 hours
- Housing: in completely air conditioned rooms in macrolon cages in groups of 5 animals
- Diet: Rattendiat Altromin 1324 (ad libitum):
- Water: tap water from plasic bottles (ad libitum):
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3
- Humidity (%): 50+-20
- Photoperiod: 12 hours daily

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Details on oral exposure:

concentration in vehicle: 25% (w/w)

Doses:

see below

No. of animals per sex per dose:

5 females: dose: 4000 mg/kg bw, application volume: 16 ml/kg bw
5 males and 5 females: dose: 5000 mg/kg bw, application volume: 20 ml/kg bw

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily and weighing: once per week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ observation

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

> 4 000 - < 5 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

During the 14-days observation period
after application of 5000 mg/kg bw (5 males and 5 females) one male and four females died
after application of 4000 mg/kg bw ( 5 females) one female died

Clinical signs:

other: Squatting posture, decreased spontaneous activity, prone position, flanks pinched in, irregular respiration, diarrhoe. One day after application no more respiration depression but cat bristling pale and yellow skin, dark yellow urine from day 6 after appl

Gross pathology:

section of the animals that died during the observation period:
content of stomach and intestine was yellow to orange yellow

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 (female rats): 4000 - 5000 mg/kg bw
LD50 (male rats): > 5000 mg/kg bw

Executive summary:

The substance was tested for acute oral toxicity according to OECD guideline 401. 5 male and 5 female Wistar rats were administered a dose of 5000 mg/kg bw and 5 female Wistar rats a dose of 4000 mg/kg bw.During the 14 days observation period after the application one male and four female animals from the 5000 mg/kg bw - group died and one female out of the 4000 mg/kg bw - group.

The LD50 for female rats is therefore between 4000 and 5000 mg/kg bw and for male rats greater than 5000 mg/kg bw.