Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-465-8 | CAS number: 12005-21-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
A chemical safety assessment and chemical safety report according to Art. 14 REACH is not required for the registration of a substance in tonnage band 1-10 tonnes. Therefore no DNELs have been derived for this substance.
Acute Toxicity
The variations L181 and L175G25C4G were tested for acute oral toxicity in a GLP guideline studies according to OECD 423.
The variation L175G225C4G was tested for acute toxicity via the inhalation route in a GLP guideline study according to OECD 403.
The variation L181 was tested for acute dermal toxicity in a GLP guideline study according to OECD 402.
Both variations did not exhibit any acute toxicity via any route of exposure.
The studies for the inhalation route and the dermal route are not required under REACH for the tonnage band 1 - 10 t/a. The results of the 4 studies on acute toxicity reveal the same toxicological profile for both variations. The same toxicological profile is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
Irritation / Corrosion
The variation L181 was tested for the potential to cause skin irritation in a GLP guideline studies according to OECD 404.
The substance did not exhibit skin irritation or skin corrosion.
The same profile is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
The variations L181 and L175G25C4G were tested for the potential to cause eye irritation in a GLP guideline studies according to OECD 405.
Both variations did not exhibit eye irritation or eye corrosion.
The results of the 2 studies on eye irritation reveal the same profile for both variations. The same result is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
Sensitisation
The variations L181 and L175G25C4G were tested for their skin sensitising potential in GLP guideline studies according to OECD 429 (modified).
Both variations did not reveal any sensitising properties in the local lymph node assay (modified).
The same result is expected for other variations of the substance pentaaluminium triyttrium dodecaoxide.
Genetic Toxicity
The variations L181 and L175G25C4G were tested for genetic toxicity in vitro.
The substance is completely insoluble in water, DMSO, ethanol, acetone, tetrahydrofurane or isopropanol. The substance is not bioavailable for the bacterial cell in the Ames test or other in vitro test methods due to its insolubility. The substance is not capable of interfering with the genome in the bacterial cell. Hence, the Ames-test is negative as a basic principle.
The same applies for potential mutagenic activity under natural conditions both for L181 and L175G25C4G as well as other variations of the substance pentaaluminium triyttrium dodecaoxide.
Based on the data available no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
