Registration Dossier
Registration Dossier
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EC number: 936-349-9 | CAS number: 1312304-36-1
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- yes
- Remarks:
- the test was performed on base of the new OECD 209 (2010) and considered the Question-and-Answer Document by the German Federal Environment Agency (Version 2012-03-02).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
- Cas Number:
- 1312304-36-1
- Molecular formula:
- C11H12ClN3O4
- IUPAC Name:
- methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate
Constituent 1
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 3 h
- Remarks on exposure duration:
- 3 hours with permanent aeration
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 11.263 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: lower 95% CL= 7.293 and upper 95% CL=17.466
Applicant's summary and conclusion
- Conclusions:
- The EC50 is higher than 100 mg/L. The NOEC is equal or higher than 100 mg/L.
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