4-methylpentan-2-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1951

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

RANGE-FINDING TOXICITY DATA: LIST IV

Author:

Smyth HF, Carpenter CP & Weil CS

Year:

1951

Bibliographic source:

AMA Arch Ind Hyg Occup Med (1951) 4:119-122

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1948

Report date:

1948

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

Insufficient reporting of methodology and individual results

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methylpentan-2-ol

EC Number:

203-551-7

EC Name:

4-methylpentan-2-ol

Cas Number:

108-11-2

Molecular formula:

C6H14O

IUPAC Name:

4-methylpentan-2-ol

Details on test material:

- Name of test material (as cited in study report): 2-methyl-2-pentanol (methyl isobutyl carbinol)

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: Not reported
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: Not reported
- % coverage: Not reported
- Type of wrap if used: Not reported


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not reported
- Time after start of exposure: Not reported


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported
- Concentration (if solution): Not reported
- Constant volume or concentration used: Not reported


VEHICLE
- Amount(s) applied (volume or weight with unit): Not reported
- Concentration (if solution): Not reported
- Lot/batch no. (if required): Not reported
- Purity: Not reported

Duration of exposure:

4 days

Doses:

Not reported

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Not reported
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Not reported

Statistics:

Standard deviations for LD50 value calculated by the method of Thompson

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3.56 other: mL/kg body weight

95% CL:

2.72 - 4.76

Remarks on result:

other: = 2870 mg/kg (calculated with a density of 0.807)

Mortality:

Not reported

Clinical signs:

other: Not reported

Gross pathology:

Not reported

Other findings:

Not reported

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)

Executive summary:

The potential acute dermal toxicity of methyl i-butylcarbinol as assessed in rabbits (Smyth, 1951). As this test was conducted by the same investigators as discussed above, the results are deemed reliable, despite the lack of methodolgical details. The dermal LD50 of methyl i-butylcarbinol in rabbits was reported to be 3.56 mL/kg (2870 mg/kg) body weight.