Registration Dossier
Registration Dossier
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EC number: 205-480-7 | CAS number: 141-32-2
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication, with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis to butyl acrylate in spectacle frames.
- Author:
- Hambly EM and Wilkinson DS
- Year:
- 1 978
- Bibliographic source:
- Contact dermatitis 4: 115
Materials and methods
- Type of sensitisation studied:
- skin
- Principles of method if other than guideline:
- A 35-year-old woman with eczema on both sides of her nose after wearing spectacles with plastic nasal rests was patch tested with butyl acrylate in 1% olive oil.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl acrylate
- EC Number:
- 205-480-7
- EC Name:
- Butyl acrylate
- Cas Number:
- 141-32-2
- Molecular formula:
- C7H12O2
- IUPAC Name:
- butyl prop-2-enoate
- Test material form:
- other: liquid
Constituent 1
Method
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Vehicle / solvent: 1% Olive oil
Results and discussion
- Results of examinations:
- Patch test was positive on day 2 and 4 after administration. The patient returned on the 16th day having again worn her spectacles for 10 days. She had developed a widespread eczema. The patch test site to butyl acrylate had flared and was bullous.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
