Registration Dossier
Registration Dossier
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EC number: 231-598-3 | CAS number: 7647-14-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study methology followed appeared to be equivalent or similar to the standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Details on test material:
- - Name of test material (as cited in study report): Salt, common salt, halite, table salt, rock salt, sea salt
- Molecular weight: 58.45
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified in the report
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- Sodium chloride was moistened with sufficient water to make a paste
- Duration of exposure:
- not specified in the report
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- 5 rabbits
- Control animals:
- not specified
- Details on study design:
- not specified in the report
- Statistics:
- not specified in the report
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality was observed
- Clinical signs:
- other: no signs of toxicity observed
- Gross pathology:
- no significant findings were noted at necropsy
- Other findings:
- slight erythema was observed
Any other information on results incl. tables
not applicable
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, sodium chloride is not classified according to EU Annex VI.
- Executive summary:
A dermal toxicity study was conducted in rabbits and the LD50 value was greater than 10000 mg/kg and hence not classified according to EU Annex VI
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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