Registration Dossier
Registration Dossier
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EC number: 204-002-4 | CAS number: 112-75-4
Endpoint summary
Administrative data
Description of key information
Full details of these endpoints are provided in the IUCLID dossier and they are considered reliable. The substance is considered "Harmful if swallowed" (Acute tox 4).
Results are presented below:
Female animals: 1320 mg/kg body weight
Male animals did not react more sensitive
Key value for chemical safety assessment
Additional information
According to the key study and the directive 83/467/EC, the product has to be labelled as hazardous with R22 "Hazardous in case of digestion". The testing of acute toxicity of the substance in the Wistar rat gave the following dosage LD50:
Female animals: 1320 mg/kg body weight
Male animals did not react more sensitive
Mortality was observed by the 9th day after gavage
Animals showed besides from unspecific poisoning symptoms an influence movement of body and diarrhoea was observed. Surviving animals did not show symptoms anymor after the 8th day.
According to the supporting study, the acute oral toxicity of the substance was investigated in two of five male and five female CD rats. The animals were started overnight priot to dosing. The test material was administered at dosages of 2000 or 500 mg/kg, at a constant volume-dosage of 10 ml/kg in maize oil. Mortality and signs of reaction to treatment were recorded during a subsequent 14 -day observation period; the surviving animals were killed on the following day. All animals were subjected to necropsy.
Under the conditions of this study the acute oral medin lethal dosage (LD50) was 2116 mg/kg for male and female animals.
Accordingly, the substance was assigned to the class "low oral toxicity"
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
