Registration Dossier
Registration Dossier
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EC number: 629-776-4 | CAS number: 308065-15-8
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Calculation for main component of Fatty acids, C12-14 (even numbered), methyl esters
- Justification for type of information:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 3.016E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 7.283 yr
- Key result
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 266 d
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Calculation for main component of Fatty acids, C12-14 (even numbered), methyl esters
- Justification for type of information:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
- Principles of method if other than guideline:
- Calculation based on HYDROWIN v2.00, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 3.016E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 7.283 yr
- Key result
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 266 d
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Referenceopen allclose all
Result refers to the uncharged molecule.
Result refers to the uncharged molecule.
Description of key information
Not relevant due to ready biodegradability
Key value for chemical safety assessment
Additional information
No experimental data evaluating the hydrolysis of Fatty acids, C12-14, methyl esters (CAS No. 308065-15-8) are available. However, according to Regulation (EC) No. 1907/2006, Annex VIII, column 2, testing for hydrolysis is not required since the substance is considered to be readily biodegradable. In addition, results from supporting QSAR estimations calculated for the main individual fatty acid components (C12 and C14)(HYDROWIN v2.00) indicate that hydrolysis is not expected to be a relevant degradation pathway for this substance, with half-lives of 7.3 years (pH 7) and 266 days (pH 8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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