Registration Dossier
Registration Dossier
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EC number: 412-060-9 | CAS number: 136210-32-7 DESMOPHEN VP-LS 2973 E; DESMOPHEN VP-LS 2975 E; DESMOPHEN VP-LS 2985 E
Endpoint summary
Administrative data
Description of key information
Additional information
Stability (hydrolysis):
The stability of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester towards hydrolysis was determined according to the OECD-guideline 111 (Bayer Industry Services, 2006). Based on kinetic parameters, the following dissipation half-lives for a temperature of 25 °C were extrapolated based on the Arrhenius equation:
pH 4 (25 °C): t1/2: 655 h
pH 7 (25 °C): t1/2: 25.4 h
pH 9 (25 °C): t 1/2: 16.8 h
Bis-aspartic-mono-acid triethyl ester, bis-aspartic-di-acid diethyl ester, bis-aspartic-tri-acid monoethyl ester and bis-aspartic-tetra-acid of aspartic acid, N,N'-[methylenebis(2 -methyl-4,1-cyclohexanediyl)]bis-,1,1',4,4'-tetraethyl ester were determined as hydrolysis products by means of an HPLC-MS method.
Biodegradation (in water, screening test):
Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester is neither readily, nor inherently biodegradable (Bayer AG, 1998a; Currenta, 2009a)
Adsorption / desorption:
The potential of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-,1,1',4,4'-tetraethyl ester to sorb on soil or sediment was determined according to EU-Method C.19 (HPLC-Method) yielding a logKoc between 4.2 and 5.1 (Bayer AG, 2003). The sorption coefficient was determined at pH 6 and pH 8 showing that the sorption behaviour does not depend on the prevailing pH.
According to the classification of Swann et al. (1983), aspartic acid, N,N'-[methylenebis(2 -methyl-4,1-cyclohexanediyl)]bis-,1,1',4,4'-tetraethyl ester has a high potential to sorb on soil.
Henry's Law constant
Aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester is characterised by a calculated Henry Law Constant of 0.24 Pa*m³/mol (Currenta, 2009b). According to Thomas, cited in the "Handbook of Chemical property Estimation Methods" (Lyman, 1980), the substance tends to partition in water and volatilisation rates are controlled by the slow diffusion through the air. Therefore, the substance has to be scored as being slightly volatile from water.
Bioaccumulation:
A study to investigate the potential of aspartic acid, N,N'-[methylenebis(2-methyl-4,1-cyclohexanediyl)]bis-, 1,1',4,4'-tetraethyl ester to accumulate in fish yielded an uptake efficiency of 0.25 % (Currenta, 2010a). The study clearly shows that the test item has no significant potential for bioaccumulation.
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