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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the rodent mieronueleus assay in the screening of IARC carcinogens (Groups 1, 2A and 2B) The summary report of the 6th collaborative study by CSGMT/JEMS - MMS
- Author:
- Morita, T. et al.
- Year:
- 1 997
- Bibliographic source:
- Mutation Research 389 3-122
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Type of assay:
- other: micronucleus assay
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2λ⁶-oxathiolane-2,2-dione
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (ad libitum): commercial pellets
- Water (ad libitum): yes
ENVIRONMENTAL CONDITIONS
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - saline
- Duration of treatment / exposure:
- - animals were treated with the test substance twice (24 h intervall) and peripheral blood was collected up to 72 h after last treatment
- Frequency of treatment:
- - twice (24 h intervall)
- Post exposure period:
- - 24, 48, 72 h
Doses / concentrations
- No. of animals per sex per dose:
- - 5 male mice per dose
- Control animals:
- yes
- Positive control(s):
- - Mitomycin C
- Route of administration: ip
- Doses / concentrations: 0.5 mg/kg (single dose)
Examinations
- Tissues and cell types examined:
- - peripheral blood reticulocytes were used for analyses
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION:
- The highest dose was fixed by the preliminary dose-finding test (based on mortality)
METHOD OF ANALYSIS:
- Micronucleated reticulocyte frequencies were based on the observation of at least 1000 polychromatic reticulocytes - Statistics:
- When the control data were acceptable, the increase in micronucleus frequency against the concurrent negative control data were evaluated using a conditional binomial test and the dose response relationship using the Cochran-Armitage trend test were evaluated. When these were both significant, the data was declared positive. If neither step showed significance, the data was judged negative. All other cases were called inconclusive.
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- positive
- Toxicity:
- yes
- Remarks:
- can be assumed, since the highest dose tested was fixed by a preliminary dose-finding test
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
Summary of the micronucleus assay results:
% micronucleated reticulocytes |
|||||||
|
|||||||
dose |
0 h |
24 h |
48 h |
72 h |
|||
mg/kg bw |
mean SD |
mean SD |
p |
mean SD |
p |
mean SD |
p |
|
|
|
|
|
|
|
|
9 |
0.08± 0.04
|
0.17± 0.10
|
0.151
|
0.10± 0.13
|
0.500
|
0.08± 0.10
|
0.623
|
18 |
0.10± 0.11
|
0.23± 0.10
|
0.058 |
0.10± 0.11
|
0.613 |
0.07± 0.05
|
0.828 |
36 |
0.12± 0.08
|
0.87± 0.53
|
< 0.001 |
0.63± 0.16
|
< 0.001 |
0.28± 0.16
|
0.032 |
72 |
0.10± 0.09
|
1.92± 0.99
|
< 0.001 |
1.68± 0.50
|
< 0.001 |
0.27± 0.14
|
0.026 |
p: value of the pairwise comparison
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.