Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-189-2 | CAS number: 52793-11-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-11-07 to 1989-11-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to EG-Guideline B.4. 84/449/EWG, OECD 404 and under GLP.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5'-chloro-2'-methoxyacetoacetanilide
- EC Number:
- 258-189-2
- EC Name:
- 5'-chloro-2'-methoxyacetoacetanilide
- Cas Number:
- 52793-11-0
- Molecular formula:
- C11H12ClNO3
- IUPAC Name:
- N-[5-chloro-2-(methoxyacetyl)phenyl]acetamide
- Reference substance name:
- Acetessig-4-chlor-o-anisidid
- IUPAC Name:
- Acetessig-4-chlor-o-anisidid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Appearance: white powder
Purity: > 99%
Lot: T021
Storage: in the dark at 20°C under a hood
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: NaCL solution
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- after 30-60 min, 24, 48 and 72 hours
- Number of animals:
- 3 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 30-60 min till 3 days
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 30-60 min till 3 days
- Score:
- 0
- Other effects:
- No.
Any other information on results incl. tables
Female rabbits:
Erythema, overall mean: 0.0
Oedema, overall mean: 0.0
The means have been calculated using the day 1,2 & 3 values.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Due to the test results, the test item is not irritating to the rabbit skin.
- Executive summary:
The study was performed according to EG-Guideline B.4. 84/449/EWG, OECD 404 and under GLP.
Due to the test results, the test item will not be classified as irritating to the rabbit skin and does not require labelling according toRegulation 1272/2008/EEC (CLP) and according to Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
