Registration Dossier
Registration Dossier
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EC number: 276-627-0 | CAS number: 72388-18-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Conclusions:
- Experimental data on in vitro mutagenicity on bacteria are available to 7 representatives of the category of Guerbet alcohols. Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols.
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- lymphocytes: human
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Conclusions:
- The test substance 2-hexyldecan-1-ol has shown no evidence of causing an increase in the frequency of structural chromosome aberrations in this in vitro cytogenetic test system, under the experimental conditions described.
Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols. - Executive summary:
The test substance 2 -hexyldecan-1 -ol has shown no evidence of causing an increase in the frequency of structural chromosome aberrations in an in vitro cytogenetic test system, under the experimental conditions described.
Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols.
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Conclusions:
- The test substance 2-hexyldecan-1-ol did not demonstrate mutagenic potential in this in vitro HPRT cell mutation assay, under the experimental conditions described.
Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols. - Executive summary:
The test substance 2-hexyldecan-1-ol did not demonstrate mutagenic potential in this in vitro HPRT cell mutation assay, under the experimental conditions described.
Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Experimental data on in vitro mutagenicity on bacteria are available to 7 representatives of the category of Guerbet alcohols. All tests are negative. Studies on mammalian cells are only available for the C16 Guerbet alcohol 2 -Hexyldecan-1-ol (CAS-No. 2425-77-6). Both a cytogenetic assay (chromosome aberration test) as well as a gene mutation study (HPRT test) are negative. Due to the similar structure with no additional functional groups these data can be cross-read to the whole category of Guerbet alcohols.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Avalaible data are conclusive but not sufficient for classification of 2 -dodecylhexadecan-1-ol with regard to mutagenicity / genotoxicity.
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