Registration Dossier
Registration Dossier
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EC number: 228-085-1 | CAS number: 6117-80-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo study performed in year 1959
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficient data available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- But-2-ene-1,4-diol
- EC Number:
- 203-787-0
- EC Name:
- But-2-ene-1,4-diol
- Cas Number:
- 110-64-5
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 2-Butene-1,4-diol
- Reference substance name:
- (Z)-2-butene-1,4-diol
- EC Number:
- 228-085-1
- EC Name:
- (Z)-2-butene-1,4-diol
- Cas Number:
- 6117-80-2
- Molecular formula:
- C4H8O2
- IUPAC Name:
- but-2-ene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): Buten-2-diol-1,4
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect observed
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect observed
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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