Registration Dossier
Registration Dossier
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EC number: 220-150-2 | CAS number: 2643-07-4
Endpoint summary
Administrative data
Description of key information
Irritation:
- skin: irritating
- eye: not irritating
Key value for chemical safety assessment
Additional information
Skin irritation:
In a primary skin irritation study (Draize test) with undiluted test substance a 24-hour exposure under an occlusive coverage caused individual mean scores (24, 48, 72 h) for erythema/edema of 2.0/2.0 for all three rabbits. After 8 days, surface necroses were observed in 2 animals, parchmentlike necrosis in 1 animal. Strong skaling was observed after 8 days (BASF AG, 1980).
Eye irritation:
In a Draize test, 0.1 ml undiluted test substance resulted in individual mean individual mean cornea/iris/conjunctivae/chemosis scores (24, 48, 72 h) of 0/0/1/0, 0/0/1.3/0 and 0/0/1.3/0 for the 3 animals tested. At the end of the observation period (8 d), only slight redness of the conjunctivae was still present in one animal (BASF AG, 1980).
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
Irritating to skin, R38
GHS classification according toAnnex I 1272/2008 CLP (EU GHS):
- Skin corrosion/irritation: Category 2
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