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EC number: 216-904-5 | CAS number: 1694-31-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound tert-Butyl 3-oxobutanoate (CAS no. 1694 -31 -1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical tert-Butyl 3-oxobutanoate is expected to be readily biodegradable.
Biodegradation in water and sediment
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound tert-Butyl 3-oxobutanoate (CAS No. 1694 -31 -1). If released in to the environment, 34.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of tert-Butyl 3-oxobutanoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of tert-Butyl 3-oxobutanoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0768%), indicates that tert-Butyl 3-oxobutanoate is not persistent in sediment.
Biodegradation in soil
The half-life period of tert-Butyl 3-oxobutanoate (CAS No. 1694 -31 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 62.6% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of tert-Butyl 3-oxobutanoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of tert-Butyl 3-oxobutanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data for the target compound tert-Butyl 3-oxobutanoate (CAS No. 1694-31-1) and various supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction using theEstimation Programs Interface Suite, the biodegradation potential of the test compound tert-Butyl 3-oxobutanoate (CAS no. 1694 -31 -1) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical tert-Butyl 3-oxobutanoate is expected to be readily biodegradable.
For the test chemical,biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance (from authoritative databases and secondary source, 2018). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) and other guideline "Biodegradation test of chemical substance by microorganisms etc." under aerobic conditions. Activated sludge (non-adapted) was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 83, 100 and 95% by BOD, GC and TOC removal parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
Another biodegradation study from authoritative database (HSDB, 2017) was conducted for 20 days for evaluating the percentage biodegradability of test substance. The study was performed under aerobic conditions at a temperature of 20°C.Settled sewage seed was used as a test inoculums for the study. The percentage degradation of test substance was determined to 5.6, 40, 62.8 and 69.6% by BOD parameter after 5, 10, 15 and 20 days, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
In a supporting weight of evidence study from authoritative database (2017) and secondary source for the test chemical,biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test) under aerobic conditions at a temperature of 22°C. Activated sludge, domestic (non-adapted) taken from waste water treatment plant was used as a test inoculums for the study. The percentage degradation of test substance was determined to be < 10, 90 and 100% by DOC removal parameter in 0.125, 2 and 5 days, respectively. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
On the basis of above results for target chemical tert-Butyl 3-oxobutanoate (from modelling database, 2017), it can be concluded that the test substance tert-Butyl 3-oxobutanoate can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface prediction model was run to predict the half-life in water and sediment for the test compound tert-Butyl 3-oxobutanoate (CAS No. 1694 -31 -1). If released in to the environment, 34.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of tert-Butyl 3-oxobutanoate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of tert-Butyl 3-oxobutanoate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0768%), indicates that tert-Butyl 3-oxobutanoate is not persistent in sediment.
Biodegradation in soil
The half-life period of tert-Butyl 3-oxobutanoate (CAS No. 1694 -31 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database. If released into the environment, 62.6% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of tert-Butyl 3-oxobutanoate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of tert-Butyl 3-oxobutanoate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance tert-Butyl 3-oxobutanoate can be considered to be readily biodegradable in nature.
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