Registration Dossier
Registration Dossier
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EC number: 259-226-5 | CAS number: 54553-91-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Guideline:
- other: Appraisal of the safety of chemicals in foods, drugs and cosmetics (FDA)
- Principles of method if other than guideline:
- Guidelines were not available when study was conducted. Basically according to OECD401.
- GLP compliance:
- no
- Remarks:
- GLP was not implemented at the time of the study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzene-1,2,4,5-tetracarboxylic acid, compound with 4,5-dihydro-2-phenyl-1H-imidazole (1:2)
- EC Number:
- 259-226-5
- EC Name:
- Benzene-1,2,4,5-tetracarboxylic acid, compound with 4,5-dihydro-2-phenyl-1H-imidazole (1:2)
- Cas Number:
- 54553-91-2
- Molecular formula:
- C10H6O8.2C9H10N2
- IUPAC Name:
- benzene-1,2,4,5-tetracarboxylic acid, compound with 4,5-dihydro-2-phenyl-1H-imidazole (1:2)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- 0.71; 1.00; 1.41; 2.00 g/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 980 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on this study conducted by an appraisal of the safety of chemicals in foods, drugs and cosmetics (Food and Drug Association) the LD50, oral, rat was determined to be 980 mg/kg bw.
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