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EC number: 227-770-2 | CAS number: 5973-71-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
In Desmodesmus subspicatus, the 72-h ErC50 and ErC10 values for growth rate are 16.6 mg/L and 14.2 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 16.6 mg/L
- EC10 or NOEC for freshwater algae:
- 14.2 mg/L
Additional information
The toxicity to aquatic algae (D. subspicatus) was examined in a study in accordance with OECD guideline 201 and in compliance with GLP criteria (Safepharm Laboratories Ltd, 2007). In this study algae were exposed to nominal concentrations of 0 (control), 6.25, 12.5, 25, 50 and 100 mg/L (3 replicate flasks per concentration) for 72 hour. Samples of the algal populations were removed daily and cell concentrations determined for each control and treatment group. Analysis of the test preparations at 0 hours showed measured test concentrations to be near nominal. Analysis of the test preparations at 72 hours showed a concentration dependent decline in measured concentrations in the range 12% to 48% of nominal. This decline was in-line with the preliminary stability analyses that indicated that the test material is unstable in the light. Geometric mean measured concentrations were 2.34, 6.09, 15.4, 35.1 and 57.5 mg/L. First at a test concentration of 25 mg/L was inhibition of algal growth observed (20%). At the two highest concentrations algal growth inhibition was 100%. Based on these findings the 72-h ErC10 and 72-h ErC50 values were determined at 14.2 and 16.6 mg/L, respectively (based on geometric mean measured concentrations).
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