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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP Compliance, not OECD guideline

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 92/69 EEC, B.3
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
421-920-2
EC Name:
-
Cas Number:
154862-43-8
Molecular formula:
C53-H58-O6-P2
IUPAC Name:
3,9-bis[2,4-bis(2-phenylpropan-2-yl)phenoxy]-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane

Test animals

Species:
other: Rat, WISTAR

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: Polyethylene glycol PEG 400
Duration of exposure:
24h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: There were no signs of systemic toxicity.
Gross pathology:
Effects on organs:
MACROSCOPIC FINDINGS: No macroscopic findings were noted.
Other findings:
Signs of toxicity (local):
No local effects noted.

Applicant's summary and conclusion

Interpretation of results:
other: not classified