Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: in silico
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
EC Number:
230-191-8
EC Name:
1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
Cas Number:
6969-71-7
Molecular formula:
C6H5N3O
IUPAC Name:
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

Test animals

Species:
rabbit

Results and discussion

In vivo

Results
Remarks on result:
other: No alert.

Applicant's summary and conclusion

Interpretation of results:
other: no alert
Conclusions:
No alert came be observed for Skin Irritation (even though with low reliability index) .