Registration Dossier
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EC number: 942-072-4 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 211).
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity of Fatty
acids, coco, decyl esters (CAS 93455-79-9) to aquatic invertebrates are
available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a
read-across to the structurally related source substance Fatty acids,
C8-10, C12-18-alkyl esters (CAS 95912-86-0) was conducted. The
read-across substance is representative to evaluate the long-term
toxicity of Fatty acids, coco, decyl esters (target substance) to
aquatic invertebrates.
The target substance is a UVCB substance specified by mainly C12 linear
fatty acids esterified with a linear alcohol of a chain length of C10.
The source substance Fatty acids, C8-10, C12-18-alkyl esters is a UVCB
substance predominantly consisting of esters with a C8-C10 fatty acid
and a C12-C14 alcohol moiety. Comparing both substances it can be seen
that they have a very similar structure. Thus, it is considered
justified to use the source substance to predict the long-term toxicity
to aquatic invertebrates of the target substance. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
The study with the read-across substance Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was performed according to OECD 211 (GLP; Salinas, 2013). Daphnia magna was exposed to a nominal loading rate of 10 mg/L (Water Accommodated Fraction). Chemical analysis of the test substance concentrations was not possible since no suitable analytical method could be developed to detect the test substance. No effects on reproduction of D. magna were observed up to the water solubility limit (< 0.05 mg/L) resulting in a NOELR (21 d) ≥ 10 mg/L.
Based on the results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Fatty acids, coco, decyl esters will not exhibit chronic effects to aquatic invertebrates up to the limit of water solubility.
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