Registration Dossier
Registration Dossier
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EC number: 260-126-9 | CAS number: 56358-17-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Concentrated vapour inhalation consists of subjecting 12 rats to a flowing stream of vapor-ladened air for a total of 7 hours.
- GLP compliance:
- no
- Test type:
- other: Inhalation-risk-test
Test material
- Reference substance name:
- N-(2-ethylhexyl)naphthalen-2-amine
- EC Number:
- 260-126-9
- EC Name:
- N-(2-ethylhexyl)naphthalen-2-amine
- Cas Number:
- 56358-17-9
- Molecular formula:
- C18H25N
- IUPAC Name:
- N-(2-ethylhexyl)naphthalen-2-amine
- Details on test material:
- - Name of test material (as cited in study report): N-(2-Ethylhexyl)-2-napthalinamin
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean weight males: 203 g (1st experiment) 220 g (2nd), mean weight females: 179 g (1st), 188 g (2nd)
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- no data
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- according to raw data ca. 0.11 mg/l
- No. of animals per sex per dose:
- 6 (3/sex/dose first experiment, 3/sex/dose 2nd experiment)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 11 mg/L air
- Exp. duration:
- 7 h
- Remarks on result:
- other: concentrated vapour-air mixture
- Mortality:
- No mortalities occured after exposing 12 rats for 7 hours to vapor-air mixture
- Clinical signs:
- other: none
- Body weight:
- no data
- Gross pathology:
- no findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
