Octyl (R)-2-(4-chloro-2-methylphenoxy)propionate

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: published data, documentation insufficient for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase

Author:

Moody DE et. al.

Year:

1991

Bibliographic source:

Toxicology Letters 59, 175-185

Reference 2

Reference Type:

secondary source

Title:

No information

Author:

The Danish Environmental Protection Agency

Year:

1998

Bibliographic source:

Mecoprop-P, EU Review Programme on active substances in Plant Protection Products, Scientific Evaluation and Assessment, Draft December 1998 (Volume 3, Annex B, ) and Addendum II July 2002; see also SANCO/3065/99-Final, 2003

Materials and methods

Administration / exposure

Details on study design:

Cited from Mecoprop-P, EU Review Programme on active substances in Plant Protection Products, Scientific Evaluation and Assessment, The Danish Environmental Protection Agency, Draft December 1998 (Volume 3, Annex B) and Addendum II July 2002:
"Three male Swiss Webster mice were dosed with daily i.p. injections of 100 mg/kg bw of racemic mecoprop (purity not specified) during three days. The test substance was suspended in corn oil and a volume of 1.0 ml/kg bw was used for the i.p. injection. Four control mice received i.p. injections with corn oil only. After the last injection the animals were killed and enzyme assays were performed on liver homogenates to assess any influence of the treatment on the metabolizing enzymes.
The study was not conducted according to any guidelines. No GLP statement present.
The study is considered appropriate for its purpose."

Results and discussion

Details on results:

Cited from Mecoprop-P, EU Review Programme on active substances in Plant Protection Products, Scientific Evaluation and Assessment, The Danish Environmental Protection Agency, Draft December 1998 (Volume 3, Annex B) and Addendum II July 2002:
"Results: Originally a mecoprop dose of 250 mg/kg bw was used. However, this dose was lethal to all the test animals, whereafter a dose of 100 mg/kg bw was used.
Mecoprop treatment caused significantly increased activity of aminopyrine N-demethylase, cytosolic epoxide hydrolase and carnitine acetyltransferase. The latter enzyme is found to be a fairly sensitive indicator for peroxisome proliferation.
It was concluded that mecoprop (and other herbicides tested in the assay) significantly increased one or more of the liver enzymes tested.
Discussion and conclusion: The activity of liver enzymes was increased by mecoprop in mice after acute exposure. Thus it was shown that mecoprop has the potential to alter the liver function."