Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Methyldiacetoxyisopropoxy silane is hydrolytically unstable (DT50 (pH 7) < 4 h)
Key value for chemical safety assessment
Additional information
Two studies investigating the susceptibility of methyldiacetoxyisopropoxy silane (CAS No. 329039-38-5) to hydrolyze are available. A preliminary test was conducted by Reimer (2002) according to OECD Guideline 111 (Hydrolysis as a Function of pH), under GLP conditions. The test substance was incubated in 3 buffered solutions at pH 5, 7 and 9 at 22 °C and hydrolysis followed by determination of the concentration of acetic acid (transformation product) by HPLC. The results from this test showed complete hydrolysis of the substance within 4 hours in all solutions. An additional study was performed by Sargent (2001) once more according to OECD Guideline 111. In this study, the hydrolytic process was monitored following the concentration of isopropanol (transformation product) in buffered solutions at pH 4, 7 and 9 at 22 °C. The test substance hydrolyzed completely into isopropanol, acetic acid and silanols within 20 minutes in all solutions. Based on the above information, methyldiacetoxyisopropoxy silane is considered hydrolytically unstable.
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