Registration Dossier
Registration Dossier
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EC number: 618-990-3 | CAS number: 939961-06-5
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
- EC Number:
- 618-990-3
- Cas Number:
- 939961-06-5
- Molecular formula:
- C15H15N3O3xClH
- IUPAC Name:
- 3-amino-N-(4-carbamoylphenyl)-4-methoxybenzamide hydrochloride
- Details on test material:
- purity: 95.4 %
contains about 4.6% water
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 969 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 2.1
Any other information on results incl. tables
Preliminary Test: Water solubility below 1 g/L
Solubility test:
Three flasks containing approx. 4 g/l test substance in water were stirred for 5 h at 30 °C. Subsequently the flasks were stirred at 20 °C for 1 day, 2 days and 3 days respectively. After each day the content of one flask was filtered through a 0,45 μm membrane filter. The content of the test substance in the filtrate was determined by HPLC.
Flask No. Equilibration time pH of aqueous Test substance conc.
at 20 °C [h] solution [mg/l]
1 24 2.1 970
2 48 2.1 968
3 72 2.1 970
mean -- -- 969
HPLC
Column : Synergi Polar RP, 250 mm x 4,6 mm ID, 4 μm Eluent A : acetonitrile/water with 0,05mol/l tetrabutyl ammonium hydrogensulfate = 5/95 Eluent B : acetonitrile/ water = 95/5
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The water solubility of the substance is 969 mg/L at 20°C. - Executive summary:
The water solubility of the substance was determined according to OECD guideline 105 with the flask method. It was found to be 969 mg/L at 20 °C.
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