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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
other: All information in this endpoint has been provided by the ECHA using 12 years rule and this data is not owned by the registrant. The reliability is estimated to be at least level 2 at a minimum. Therefore the reliability statement below can be used:
Rationale for reliability incl. deficiencies:
other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of relevant results.

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.4
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
417-560-0
EC Name:
-
Cas Number:
67881-98-5
Molecular formula:
C11H22NO6P
IUPAC Name:
trimethyl[2-({2-[(2-methylprop-2-enoyl)oxy]ethyl phosphonato}oxy)ethyl]azanium
Details on test material:
No data.

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No data.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 h
Observation period:
No data.
Number of animals:
3.
Details on study design:
No data.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: mean of 24, 48 and 72 h
Score:
1
Irritation parameter:
erythema score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: mean of 24, 48 and 72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Remarks:
(Mean score 3)
Time point:
other: mean of 24, 48 and 72 h
Score:
0
Irritation parameter:
erythema score
Max. score:
1
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Max. Duration: d; Max. value at end of observation period: 0 (related to all animals)
Irritation parameter:
edema score
Basis:
animal #1
Remarks:
(Mean score 1)
Time point:
other: mean of 24, 48 and 72 h
Score:
0.67
Irritation parameter:
edema score
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: mean of 24, 48 and 72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Remarks:
(Mean score 3)
Time point:
other: mean of 24, 48 and 72 h
Score:
0
Irritation parameter:
edema score
Max. score:
1
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: Max. Duration: 96 d; Max. value at end of observation period: 0 (related to all animals)
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 7 days.
Other effects:
No data.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Based on the available information from the SNIF data, MPC is not classified as a skin irritant under Council Directive 67/548/EEC or Regulation (EC) No 1272/2008.
Executive summary:

Based on the available information from the SNIF data, MPC is not classified as a skin irritant under Council Directive 67/548/EEC or Regulation (EC) No 1272/2008. Reliability of the data is not assigned but expected to be 2 at minimum.