Registration Dossier
Registration Dossier
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EC number: 201-187-3 | CAS number: 79-22-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 - 10/1977
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Methyl chloroformate
- EC Number:
- 201-187-3
- EC Name:
- Methyl chloroformate
- Cas Number:
- 79-22-1
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- methyl chloroformate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Remarks:
- 2% solution
- Doses:
- 0.2512 ml/kg
0.3163 ml/kg
0.3981 ml/kg - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 346.6 - <= 393.1 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- other: mean LD50
- Effect level:
- 369.1 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0.2512 ml/kg mortality 0 of 10 animals
0.3163 ml/kg mortality 7 of 10 animals
0.3981 ml/kg mortality 10 of 10 animals
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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