Registration Dossier
Registration Dossier
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EC number: 700-529-3 | CAS number: 4224-62-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: This is published data and detailed test condition is not available.
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data; List VI
- Author:
- H.F.Smyth, D.P.Carpenter,C.S.Weil,U.C.Pozzani,J.A.Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, vol 23, pages 95 - 107 (1962)
Materials and methods
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentration of chemicals. Grade 1 corresponds to the least effect and grade 10 corresponds to the most serious damage.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6-Chlorohexanoic acid
- EC Number:
- 700-529-3
- Cas Number:
- 4224-62-8
- Molecular formula:
- C6H11ClO2
- IUPAC Name:
- 6-Chlorohexanoic acid
- Details on test material:
- No data available except chemical name
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- cornea opacity score
- Basis:
- other: rabbit
- Time point:
- other: not available
- Score:
- 9
- Max. score:
- 10
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Score of the eye damage/irritation based upon corneal necrosis of rabbits is 9. This means that this substance gives severe damange on eyes.
Thus we classified category 1 for eye damage/iriitation.
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