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EC number: 212-855-9 | CAS number: 873-94-9
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 3,3,5-trimethylcyclohexan-1-one. Inoculumn concentration i.e, sludge concentration used was 30 mg/l while initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 3% by O2 consumption (BOD), 9% by TOC removal and 13% degradation by Test mat. analysis (GC) in 28 days. Thus, based on percentage degradation, the test substance 3,3,5-trimethylcyclohexan-1-one was considered to be not readily biodegradable in water.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3,3,5-trimethylcyclohexan-1-one(CAS No.873 -94 -9). If released in to the environment, 26.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3,3,5-trimethylcyclohexan-1-onein water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 3,3,5-trimethylcyclohexan-1-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.131%), indicates that 3,3,5-trimethylcyclohexan-1-oneis not persistent in sediment.
Biodegradation in soil:
The half-life period of3,3,5-trimethylcyclohexan-1-one (CAS No.873 -94 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of3,3,5-trimethylcyclohexan-1-onein soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 3,3,5-trimethylcyclohexan-1-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
Various studies for the test substance 3,3,5-trimethylcyclohexan-1-one(873-94-9) and its read across substances were reviewed to summarize the following information:
In an experimental study of target substance from J-check database, Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 3,3,5-trimethylcyclohexan-1-one. Inoculumn concentration i.e, sludge concentration used was 30 mg/l while initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 3% by O2 consumption (BOD), 9% by TOC removal and 13% degradation by Test mat. analysis (GC) in 28 days. Thus, based on percentage degradation, the test substance 3,3,5-trimethylcyclohexan-1-one was considered to be not readily biodegradable in water.
The other study for the target substance was predicted where Estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound 3,3,5-trimethylcyclohexan-1-one (CAS no.873 -94 -9) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3,3,5-trimethylcyclohexan-1-one is expected to be not readily biodegradable in water.
Another experimental study for RA (CAS No.78-59-1) from J-check where Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance 3,5,5-trimethylcyclohex-2-enone. Inoculum concentration i.e, sludge concentration used was 30 mg/l while initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 1.5% by O2 consumption (BOD), 2.6% by TOC removal and 1% degradation by Test mat. analysis (GC) in 14 days. Thus, based on percentage degradation, the test substance 3,5,5-trimethylcyclohex-2-enone was considered to be not readily biodegradable in water.
Similarly in an experimental study from J-check for another RA (CAS No. 3452-97-9), Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 3,5,5-trimethylhexan-1-ol. Inoculum concentration i.e, sludge concentration used was 30 mg/l while initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was determined to be 4% by O2 consumption (BOD), 4% by TOC removal and 55% degradation by Test mat. analysis (GC) in 28 days. Thus, based on percentage degradation, the test substance 3,5,5-trimethylhexan-1-ol was considered to be not readily biodegradable in water.
Based on the data of target substance3,3,5-trimethylcyclohexan-1-one(873-94-9) and its read across chemicals 3,5,5-trimethylcyclohex-2-enone (78-59-1) and 3,5,5-trimethylhexan-1-ol (3452-97-9) both of which has 50-60% structural similarity it can be concluded that the test substance 3,3,5-trimethylcyclohexan-1-one is not expected to be readily biodegradable in water.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3,3,5-trimethylcyclohexan-1-one(CAS No.873 -94 -9). If released in to the environment, 26.2% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3,3,5-trimethylcyclohexan-1-onein water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 3,3,5-trimethylcyclohexan-1-one in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.131%), indicates that 3,3,5-trimethylcyclohexan-1-oneis not persistent in sediment.
Biodegradation in soil:
The half-life period of3,3,5-trimethylcyclohexan-1-one (CAS No.873 -94 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 72.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of3,3,5-trimethylcyclohexan-1-onein soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 3,3,5-trimethylcyclohexan-1-one, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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