Registration Dossier
Registration Dossier
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EC number: 609-724-7 | CAS number: 39605-45-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Atrazine
- EC Number:
- 217-617-8
- EC Name:
- Atrazine
- Cas Number:
- 1912-24-9
- Molecular formula:
- C8H14ClN5
- IUPAC Name:
- 6-chloro-N-ethyl-N'-isopropyl-1,3,5-triazine-2,4-diamine
- Details on test material:
- purity 96.7%
batch FL 890322
Constituent 1
- Specific details on test material used for the study:
- - Purity: 96.7%
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIF (SPS)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of exposure:
- 4 h
- Concentrations:
- 5148 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- none
- Clinical signs:
- other: Rats showed piloerection, hunched posture, dyspnea, and reduced locomotor activity. All animals recovered within 5 days.
- Gross pathology:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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