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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline comparable, non-GLP proprietray study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
Principles of method if other than guideline:
BASF in-house test methods similar to those subsequently outlined in OECD acute testing guidelines. The study design is similar to standard acute dermal method described in TG OECD 402
GLP compliance:
no
Test type:
other: various acute toxicity investigations presented in a single report
Limit test:
no

Test material

Constituent 1
Reference substance name:
ethylethanolamine
IUPAC Name:
ethylethanolamine
Constituent 2
Chemical structure
Reference substance name:
2-ethylaminoethanol
EC Number:
203-797-5
EC Name:
2-ethylaminoethanol
Cas Number:
110-73-6
Molecular formula:
C4H11NO
IUPAC Name:
2-ethylaminoethanol
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report):ethylethanolamine
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No information

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
No information available
Duration of exposure:
No information available
Doses:
No information
No. of animals per sex per dose:
No information
Control animals:
not specified
Details on study design:
In-house BASF test design, no additional information available. Methods similar to those subsequently adopted for OECD 402
Statistics:
Median lethal dose was calculated by Probit analysis using the method of FInney

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 670 mg/kg bw
Based on:
test mat.
95% CL:
> 3 030 - < 5 180
Mortality:
Mortalities occurred but no details are presented in the report
Clinical signs:
other: Following application vocalising and a'long-legged' gait were noted. The animals were initially aggressive but subsequently apathetic. Persistent necrosis was apparent from 24 h after dosing The only clinical sign observed was apathy
Gross pathology:
- Histopathology (decedent animals): cadaveric
- Histopathology (killed animals): no findings
Other findings:
No information

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose for rats for dermally administered 2-ethylethanolamine was 3670 mg/kg (confidence limit 3030 to 5180 mg/kg)
Executive summary:

The median lethal dermal dose of 2 -ethylethanolamine to rats was calculated following exposure to the unchanged test material. The rats were apathetic after dosing but no other signs of reaction to treatment were observed. After dermal treatment with 2 -ethylaminoethanol the rats showed clinical signs including screaming, aggression and long-legged gait. In the observation period apathy was observed. Further, necrosis was noted which lasted throughout the observation period. A dermal LD 50 of 3670 (3030-5180) mg/kg bw was calculated.