Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-624-5 | CAS number: 17639-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was based on EEC methodology and performed at a reputable testing facility, however no information on GLP was provided in the test report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Report states that the study was in accordance with EEC methodology however no specific method was cited.
- GLP compliance:
- not specified
- Remarks:
- No information on GLP was provided in the test report.
Test material
- Reference substance name:
- 2-Chloropropionic acid methyl ester
- IUPAC Name:
- 2-Chloropropionic acid methyl ester
- Details on test material:
- - Name of test material (as cited in study report): MeACPA/ 2-Chloropropionic acid methyl ester
- Physical state: Liquid
- Analytical purity: 99.4%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- Four hour exposure period
- Observation period:
- Eight days after dosing
- Number of animals:
- Three
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Over 72 hours observation
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Over 72 hours observation
- Score:
- 0.86
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
Any other information on results incl. tables
A summary of the results is presented in Table 1.
Rabbit Number |
E=Erythema O = Oedema |
Day |
||||||||
1* |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
||
17 |
E O |
1 1 |
2 2 |
2 2 |
2 1 |
1 1 |
1 1 |
1 0 |
1 0 |
0 0 |
18 |
E O |
1 1 |
1 1 |
1 1 |
1 1 |
1 0 |
1 0 |
1 0 |
1 0 |
0 0 |
589 |
E O |
1 1 |
0 0 |
0 0 |
0 0 |
|
|
|
|
|
*Approximately 60 minutes after removal of the dressing.
All rabbits used in the study were female.
Scores at reading times of 24, 48 and 72 hours were used to calculate the mean scores.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- Methyl-2-chloropropionic acid elicited a slight to very well defined dermal irritation after four hours exposure to rabbit skin. This irritation is not sufficient to require classification as ‘irritating to skin’.
- Executive summary:
The effect of Methyl-2-chloropropionic acid on rabbit skin was evaluated in a study in accordance with EEC methodology. The test substance (0.5 ml) was applied to three New Zealand white rabbits under a semi-occlusive dressing. After a four-hour exposure period the dressings and test substance were removed and the test sites assessed for a period of eight days after dosing.
The application resulted in a mean erythema score of 1 over the 72 hour period after dosing and a mean oedema score of 0.86 for the same time period.
These scores are insufficient to trigger classification as irritating to skin, according to the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.