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EC number: 478-310-4 | CAS number: 53803-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 478-310-4
- EC Name:
- -
- Cas Number:
- 53803-13-7
- Molecular formula:
- C9H21NO2
- IUPAC Name:
- Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid
- Test material form:
- other: Liquid
- Details on test material:
- Test was performed using commercial product DABCO TMR-7 which is 50% solution of Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid in 1,2-ethandiol, Batch #19847-85
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 1,2-ethanediol
- Details on dermal exposure:
- Prior to the day of application the dorsal area of the trunk of each animal was clipped free of hair. The area was approximately 10% of the animal's body surface.
- Duration of exposure:
- 24 hours
- Doses:
- Following dosing level was used - 2000, 1000, 400 mg/kg b.v. (related to DABCO TMR-7)
- No. of animals per sex per dose:
- 3 males and 3 females per dose.
- Control animals:
- no
- Details on study design:
- Animals were observed 1,2, and 4 hours postdose and once daily for 14 days for toxic and pharmacological effects. Body weight was recorded pre-test and at day 7 and 14.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 533 - 1 200
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 067 - 2 400
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 386 - 2 605
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 360 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 634 - 2 918
- Mortality:
- Initially three animals per sex were dosed at 2,000 mg/kg b.w. Based on the response following doses were applied
Dose Male/Female treated Mortality
400 mg/kg 3/3 0/0
1000 mg/kg 3/3 0/1
2000 mg/kg 3/3 2/2 - Clinical signs:
- other: 2000 mg/kg dose prior to mortality on day 0, cloudy discharge from the eye, instances of lethargy, nose/mouth area wet and convulsion were observed. Instances of diarrhea and few feces were observed in survivors. Dermal effects were absent throughout the
- Gross pathology:
- 2000 mg/kg dose - For animals who died, necropsy results revealed abnormalities of the treated skin.eyes, nose, mouth, pancreas spleen and liver. Necropsy of survivors were normal.
1000 mg/kg dose - animal who died showed abnormalities in anogenital area, nose/mouth area, spleen and liver
400 mg/kg - necropsy results revealed abnormalities of the pancreas and thymus
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of the 50% solution of Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid in 1,2-ethandiol is 1600 (1067-2400) mg/kg bw. The estimated dermal LD50 for Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid is therefore 800 mg/kg b.w.
- Executive summary:
The dermal LD50 for Methanaminium N,N,N-trimethyl-, salt with 2,2-dimethylpropanoic acid was determined to be 800 mg/kg b.w.
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