Registration Dossier
Registration Dossier
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EC number: 206-466-3 | CAS number: 345-92-6
Endpoint summary
Administrative data
Description of key information
Bis(4-fluorophenyl) ketone is of low dermal and inhalative acute toxicity with a dermal LD50 (rat) of > 2500 mg/kg bw (Qing_2006) and an inhalative LC50 (rat, aerosol, 4 hrs) of > 5050 mg/m3 (Zhang_2006). The LD50 value (oral) of bis(4-fluorophenyl) ketone in female and male rats was estimated to be 2000 mg/kg bw (Qing_2006). Therefore, under the conditions of the study the acute toxicity of the test substance after oral exposure in rats is moderate and bis(4-fluorophenyl) ketone has to be classified as harmful if swallowed.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Based on the results of the acute dermal and inhalation studies with bis(4 -fluorophenyl) ketone
and according to the criteria of CLP Regulation 1272/2008 no classification is required for acute dermal and inhalation toxicity. The oral LD50 value of bis(4-fluorophenyl) ketone in rats was estimated to be 2000 mg/kg bw. Thus the substance has to be classified for acute oral toxicity according CLP regulation 1272/2008, Category 4, H302: Harmful if swallowed.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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