Registration Dossier
Registration Dossier
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EC number: 602-891-7 | CAS number: 122731-59-3
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 1993 to Feb 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- rac-5-Amino-N-(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamic acid
- EC Number:
- 602-891-7
- Cas Number:
- 122731-59-3
- Molecular formula:
- C15 H15 I3 N2 O7
- IUPAC Name:
- rac-5-Amino-N-(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamic acid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- The activated sewage sludge for the inoculum was collected on the day before the start of the experiment from a municipal sewage treatment plant, predominantly dealing with domestic sewage. During the time between collection and use the sewage sludge was kept under aerobic conditions. Approximately 1 hour before the start of the incubation, aeration was discontinued and the sludge was allowed to sediment. The inoculum was obtained from the supernatant.
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- < 10
- Sampling time:
- 28 d
- Details on results:
- The ready biodegradability was studied in a DOC die away test according to OECD302E. The study was performed under GLP. The test substance was not ready biodegradable.The reference substance, sodium acetate, was degraded to more than 60% within 4 days, fulfilling the validity criterion.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test compound TAMIP diacetate (ZK91.248) was not ready biodegradable.
- Executive summary:
The ready biodegradability was studied in a DOC die away test according to OECD302E. The study was performed under GLP. The test substance was not ready biodegradable.The reference substance, sodium acetate, was degraded to more than 60% within 4 days, fulfilling the validity criterion.
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