Registration Dossier
Registration Dossier
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EC number: 600-588-4 | CAS number: 104617-50-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2004 to July 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide
- EC Number:
- 600-588-4
- Cas Number:
- 104617-50-7
- Molecular formula:
- C9 H13 O N3 S x HBr
- IUPAC Name:
- N-(2-Methyl-4,5,6,7-tetrahydro-benzothiazol-6-yl)-acetamide hydrobromide
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- -0.051
- Temp.:
- 20.5 °C
- pH:
- 5.79
- Remarks on result:
- other: flow rate 0.8 ml/min
- Type:
- log Pow
- Partition coefficient:
- -0.032
- Temp.:
- 20.5 °C
- pH:
- 5.79
- Remarks on result:
- other: flow rate 0.6 ml/min
- Details on results:
- In both valid experiments, a log Pow of the test item of< O was obtained:
- 0.055 at flow rate 0.8 ml/min. and - 0.032 at flow rate 0.6 ml/min.These values lie within the recommended range of ± 0.3 log units.
Applicant's summary and conclusion
- Conclusions:
- The log Pow was determined to be < 0. Depending on flow rate and composition of the moblie phase the determined values are -0.051 and -0.032.
- Executive summary:
A log Pow of the test item of < 0 was obtained: -0.051 at flow rate 0.8 ml/min and -0.032 at flow rate 0.6 ml/min . These values lie withtin the recommended range of +/- 0.3 log units.
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