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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from Nov 22, 2021, to Feb 15, 2022
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 59 Sieve Analysis, CIPAC MT 170 Dry Sieve Analysis of Water Dispersible Granules and CIPAC MT 169 Tap Density of Water Dispersible Granules
Deviations:
no
GLP compliance:
yes
Type of method:
sieving
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: Pfeifer & Langen GmbH & Co. KG; Lot No. L1021174
- Purity, including information on contaminants, isomers, etc.: 99.54 %

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature, protected from light
- Expiry date: 28 October 2023

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing (e.g. warming, grinding): none
Mass median aerodynamic diameter:
ca. 140 µm
Remarks on result:
other: GSD is not available
Key result
Percentile:
D90
Mean:
ca. 230 µm
Remarks on result:
other: St. dev. not available
Key result
Percentile:
D50
Mean:
ca. 140 µm
Remarks on result:
other: St. dev. not available
Key result
Percentile:
D10
Mean:
ca. 70 µm
Remarks on result:
other: St. dev. not available






The tap density of Cellobiose was found to be 0.73 g/mL.





90.2% m/m of test item particles were between 63 and 250 μm.


Sample mass used: approx. 117 g




Conclusions:
In a GLP-compliant study according to CIPAC MT 59, 170 and 169, 90.2% of particle size distribution of cellobiose was found in the range from 63 μm to 250 μm, with a MMAD of approx. 140 µm.
Executive summary:

In a GLP-compliant sieving study according to CIPAC MT 59, 170 and 169, 90.2% of particle size distribution of cellobiose was found in the range from 63 μm to 250 μm, with a MMAD of approx. 140 µm, a D10 of approx. 70 µm and a d90 of approx. 230 µm.

Description of key information

90.2% of particle size distribution of cellobiose was found in the range from 63 μm to 250 μm, with a MMAD of approx. 140 µm.

Additional information