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EC number: 205-517-7 | CAS number: 141-98-0
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.0/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: Daphnid species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.769 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: cited as a ChV value
- Details on results:
- Daphnid, 30-day,NOEC for freshwater species cited as ChV (chronic value) =0.769 mg/L (ppm)
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- Daphnid, 30-day,NOEC cited as ChV (chronic value) = 0.769 mg/L
- Executive summary:
The ECOSAR QSAR model predicts that 30-day NOECcited as a ChV (chronic value) for fresh water species would to be 0.769 mg/l therefore that the substance is effectively highly toxic to Daphnid.
Daphnid, 30-day, ChV (chronic value) = 0.769 mg/L (ppm)
Daphnid , 48-hr LC50 = 5.383 mg/L (ppm)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.0/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Mysid shrimp
- Details on test organisms:
- Scientific name: Americamysis bahia
Common name: Opossum shrimp, Mysid shrimp, Mysids - Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.179 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: cited as a ChV value
- Details on results:
- Mysid Shrimp (SaltWater), 30-day,NOEC cited as ChV (chronic value) = 0.179 mg/L (ppm)
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- Mysid Shrimp, 96 -hr, LC50=3.060 mg/L (ppm)
Mysid Shrimp (SW), 30-day, ChV (chronic value) = 0.179 mg/L (ppm) - Executive summary:
Using the EPIWIN ECOSAR QSAR model, a 30-day NOEC cited as a ChV (chronic value) for marine water (SW) aquatic invertebrates of 0.179 mg/L (ppm) was established.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1985
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Justification for type of information:
- Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate. Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .
- Qualifier:
- according to guideline
- Guideline:
- other: other: Prolonged Toxicity Test
- Principles of method if other than guideline:
- At the start of the experiments and after 16 days the lengths of daphnids exposed to the test compound were measured. The NOEC on growth is defined as the highest concentration which did not result in a significant reduction in growth at P<0.001
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 16 d
- Hardness:
- NR
- Test temperature:
- NR
- pH:
- NR
- Dissolved oxygen:
- NR
- Reference substance (positive control):
- not specified
- Duration:
- 16 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 141 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Details on results:
- A 16 d NOEC of 141 mg/L has been determined for growth rate effects to Daphnia magna of the test substance.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate . Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate . - Validity criteria fulfilled:
- not specified
- Conclusions:
- A 16 d NOEC of 141 mg/L has been determined for growth rate effects to Daphnia magna of the test substance.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate. Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate . - Executive summary:
A 16 d NOEC of 141 mg/L has been determined for growth rate effects to Daphnia magna of the test substance.
Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamateand.Therefore, the Biodegradation in water of Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.
Referenceopen allclose all
Overview of QSARs estimations on long-term aquatic toxicity of
O-isopropyl ethylthiocarbamate (IPETC ) to Daphnid
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Daphnid , 48-hr LC50 = 5.383mg/L (ppm)
Daphnid, 30-day, ChV (chronic value) = 0.769 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
The ECOSAR QSAR model predicts that 30-day NOECcited as a ChV (chronic value) for fresh water species would to be 0.769 mg/l therefore that the substance is effectively highly toxic to Daphnid.
Daphnid, 30-day, ChV (chronic value) = 0.769 mg/L (ppm)
Daphnid , 48-hr LC50 = 5.383mg/L (ppm)
Overview of QSARs estimations on long-term aquatic toxicity of O-isopropyl ethylthiocarbamate(IPETC ) to Mysid shrimp
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Mysid Shrimp, 96 -hr, LC50= 3.060/L (ppm) Mysid Shrimp (SW), 30-day, ChV (chronic value) = 0.179 mg/L (ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Mysid Shrimp, 96 -hr, LC50= 3.060mg/L (ppm)
Mysid Shrimp (SW), 30-day, ChV (chronic value) = 0.179 mg/L (ppm)
Description of key information
The ECOSAR QSAR model predicts that 30-day NOECcited as a ChV (chronic value) for fresh water species would to be 0.769 mg/l therefore the substance is effectively highly toxic to Daphnid.
Using the EPIWIN ECOSAR QSAR model, a 30-day NOEC cited as a ChV (chronic value) for marine water (SW) aquatic invertebrates of 0.179 mg/L (ppm) was established and therefore the substance is effectively highly toxic to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.769 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 0.179 mg/L
Additional information
The ECOSAR QSAR model predicts that 30-day NOECcited as a ChV (chronic value) for fresh water species would to be 0.769 mg/l therefore the substance is effectively highly toxic to Daphnid.
Using the EPIWIN ECOSAR QSAR model, a 30-day NOECcited as a ChV (chronic value)for marine water (SW) aquatic invertebrates of 0.179 mg/L (ppm) was established and therefore the substance is effectively highly toxic to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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