Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24-Aug to 10-Nov 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27th July 1995
- GLP compliance:
- no
- Type of method:
- column elution method
- Water solubility:
- > 34.72 - < 45.64 mg/L
- Temp.:
- 20 °C
- pH:
- 7
Reference
Results and discussion
Solubility experiments were run at 25 ml/hr and 12.5 ml/hr initially. The results from columns A and B appeared to indicate a rising solubility at the lower flow rate, therefore a third column was prepared (column C). Column C was run at 6.25 ml/hr.
Results from column A were not used in the calculation of final solubility as these results exceeded the 30% between-column variance limit specified in the OECD 105 guideline. Instead, the final concentration was calculated exclusively from the B and C samples.
All specified validity criteria were satisfied in this test, between-column final concentrations varied by 25.17% (<30% required).
No temperature dependence or chemical instability of the material was observed during this study.
The water solubility of [trade name] 5372 was found to be 40.18 ± 5.46 mg/l at 20 ± 0.2 °C, pH 7 using the column elution method.
Description of key information
40.18 ± 5.46 mg/l at 20 ± 0.2 °C, pH 7 (OECD 105, column elution method)
Key value for chemical safety assessment
- Water solubility:
- 40.18 µg/L
- at the temperature of:
- 20 °C
Additional information
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