Registration Dossier
Registration Dossier
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EC number: 632-619-2 | CAS number: 881685-58-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Aug 2012 to 07 Sep 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 1.1 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 25 °C
- pH:
- >= 6.48 - <= 6.79
- Conclusions:
- At 25 °C the water solubility was 1.1 mg/L in pure water with a pH of about 6.6.
- Executive summary:
The water solubility of the test substance was determined using the column elution method according to OECD TG 105 following GLP principles. At 25 °C the water solubility was 1.1 mg/L in pure water with a pH of about 6.6.
Reference
Results
Established the specificity of the method as no peak elutes at or near the retention time of the test substance from the inert carrier. No colloidal particles were observed in either experiment.
The following average solubility result at 25 °C, correct to two significant figures was obtained: 1.1 mg/L at 25 °C. The final total relative standard deviation, based on the two flow rates, is 8.6 %.
Table 1. Results
Experiment Flow rate (ml/hr) |
Sample Number |
pH |
Concentration (mg/L) |
Relative standard deviation (%) |
|||
R1 |
R2 |
R1 |
R2 |
average |
|||
12.5 |
1 |
6.51 |
6.53 |
1.088 |
1.264 |
1.10 |
8.0 |
2 |
6.58 |
6.54 |
1.064 |
1.178 |
|||
3 |
6.50 |
6.54 |
0.950 |
1.134 |
|||
4 |
6.48 |
6.56 |
1.025 |
1.105 |
|||
5 |
6.52 |
6.59 |
1.035 |
1.130 |
|||
25 |
1 |
6.60 |
6.58 |
1.002 |
1.182 |
1.06 |
9.4 |
2 |
6.62 |
6.64 |
0.975 |
1.025 |
|||
3 |
6.60 |
6.56 |
1.095 |
1.038 |
|||
4 |
6.79 |
6.70 |
1.282 |
1.001 |
|||
5 |
6.68 |
6.63 |
0.968 |
1.078 |
|||
Description of key information
Water solubility: 1.1 mg/L in pure water at 25 °C and with a pH of about 6.6, OECD TG 105, column elution method, Vijayakumar 2012
Key value for chemical safety assessment
- Water solubility:
- 1.1 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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