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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: TRD Protocol No. 31, Book 7, p.194
Principles of method if other than guideline:
Single Dermal Dose
Species Albino Male Rabbit
Condition: The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin.
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
Molecular formula:
C15 H20 O3
IUPAC Name:
Reaction mass of 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yloxy)ethyl acrylate and 2-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yloxy)ethyl acrylate
Specific details on test material used for the study:
No specific details on test material.

Test animals

Species:
rabbit
Strain:
other: Albino
Sex:
male
Details on test animals or test system and environmental conditions:
Species: Albino Male Rabbit

Administration / exposure

Type of coverage:
other: Impervious cuff
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin.
Duration of exposure:
24 hours
Doses:
5.0 g/kg
No. of animals per sex per dose:
Five
Control animals:
no
Details on study design:
No further details specified.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
One male died on Day 7.
Clinical signs:
other: Signs of intoxication: Lethargy, soft feces, diuresis. Skin Irritation: Severe erythema and edema followed by eschar formation.
Gross pathology:
Gross autopsy on survivors found one animal had 2 yellow-white lesions of the left kidney.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 greater than 5000 mg/kg
Executive summary:

Single Dermal Dose

Species: Albino Male Rabbit

Condition: The product, as received, was held under an impervious cuff in continuous 24 hour contact with closely shaven skin.

Dosage: 5.0 g/kg

Died/dosed: 1/5

LD50 greater than 5.0 g/kg