Registration Dossier
Registration Dossier
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EC number: 227-577-3 | CAS number: 5894-79-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl formylphenylacetate
- EC Number:
- 227-577-3
- EC Name:
- Methyl formylphenylacetate
- Cas Number:
- 5894-79-1
- Molecular formula:
- C10H10O3
- IUPAC Name:
- methyl 3-oxo-2-phenylpropanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 0.5 ml per application site
- Duration of treatment / exposure:
- 4h
- Observation period:
- 1, 24, 48 and 72h
- Number of animals:
- 3 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP
- Conclusions:
- Considering the reported data of this irritation study it can be stated that the test item SCH 1000 I I Fonnylester NV showed
no irritant/corrosive effects. - Executive summary:
In this irritation study the test item SCH 1000 / I Formylester NV was applied to one site of the closely clipped backs of 3 rabbits (strain NZW) at a dose of 0.5 ml per application site. The untreated other side served as control.
The application site was covered with a semi - occlusive bandage for a 4 hour - contact time.
Observations were recorded and compared to the control sites, 1 h, 24 h, 48 h and 72 hours after removal of the dressing.
The test item SCH 1000 / I Formylester NY showed no irritant effects on the intact skin after a contact time of 4 hours.
No other clinical signs oftoxicity were found.
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