Registration Dossier
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EC number: - | CAS number: -
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (56 d) ≥ 1000 mg/kg dw (OECD 222)
Key value for chemical safety assessment
Additional information
No studies are available investigating the toxicity to soil macroorganisms for fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1). Thus, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally most similar analogue substances carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) was conducted to fulfill the data requirements according to Annex VII-IX of fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1).
This read across is justified in detail in the overall summary (IUCLID chapter 6.3) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. Both substances consist of the same alcohol component (dipentaerythritol) and similar fatty acid chain lengths (C7-10 for the target substance compared to C5-9iso for the source substance, respectively).
The study with the source substance carboxylic acids, C5-9, hexaesters with dipentaerythritol (CAS 67762-52-1) was conducted according to OECD 222 (GLP) using the earthworm Eisenia fetida (Eisner, 2013).
The test substance was homogeneously mixed into artificial soil with the following nominal concentrations 62.5, 125, 500 and 1000 mg/kg dw soil. Earthworms were exposed to treated soil for four weeks. The cocoons and juvenile earthworms remained in the vessels for additional four weeks. Since no effects on reproduction and mortality were observed, the NOEC (56 d) was determined to be ≥ 1000 mg/kg dw.
Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar structure, it can be concluded that fatty acids C5-10 esters with dipentaerythritol (CAS 70983-72-1) is of low toxicity to soil macroorganisms.
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