Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Endpoint summary
Administrative data
Description of key information
The substance is not irritant to the skin.
The substance is mildly-moderately irritant to eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- not irritating.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the substance was not irritant to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Irritant / corrosive response data:
- Mild to slight irritation conjunctival redness, chemosis, tearing; iris changes, immediate washing prevented the iris changes.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, eye irritation was observed; all effects were reversible within a week. Since no scores are actually stated, the study cannot be used for classification.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.1 mL
- Number of animals or in vitro replicates:
- 6 animals
- Irritant / corrosive response data:
- Mild to moderate irritation with conjunctival redness and chemosis (6/6), tearing (6/6), corneal changes (4/6) (opacity and ulceration, corneal stippling (1/6)), iris changes (4/6); reversible within 7 days.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, eye irritation was observed; all effects were reversible within a week. Since no scores are actually stated, the study cannot be used for classification.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
According to CLP Regulation, the substance has not to be classified as skin irritant.
Data available are deemed to be inconclusive to assess eye irritation in accordance with CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
