Registration Dossier
Registration Dossier
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EC number: 835-656-4 | CAS number: 399017-10-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/06/2000-07/09/2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: GLP for chemical substances
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate hydrochloride (1:1)
- EC Number:
- 835-656-4
- Cas Number:
- 399017-10-8
- Molecular formula:
- C13H14ClNO3S
- IUPAC Name:
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate hydrochloride (1:1)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese white strain (Kbs:JW)
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Controls:
- yes
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-3
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Irritation parameter:
- edema score
- Basis:
- animal: 1-3
- Time point:
- 24/48/72 h
- Score:
- ca. 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The resultss demonstrate that Thiazole Derivative is evaluated to have slight irritation effects on the skin of rabbits under the present test condition.
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