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Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05.06.2018 - 06.09.2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
Version / remarks:
CO 2 Evolution Test", (adopted July 17, 1992).
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: ISO International Standard 10634
Version / remarks:
1995
Deviations:
no
GLP compliance:
no
Remarks:
ISO 9001 and ISO 14001 environment
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and package No.of test material: manufactured in Sevelen, lot #51716
- Expiration date of the lot/batch: 09.04.2019
- Purity test date:
Oxygen conditions:
aerobic
Inoculum or test system:
other: Activated sludge from municiipal sewage treatment plant
Details on inoculum:
The test has been accepted internationally for determining the 'ready' biodegradability of test items under aerobic conditions.
- Pretreatment: sieved 1mm
- Concentration of sludge: 2.4 g/L; 7.2 mg/L
- Initial cell/biomass concentration:
- Water filtered: yes/no
- Type and size of filter used, if any:
Duration of test (contact time):
>= 28 - <= 28 d
Initial conc.:
>= 16.5 - <= 16.5 mg/L
Based on:
test mat.
Parameter followed for biodegradation estimation:
CO2 evolution
Details on study design:
The study consisted of eight bottles:
- 2 inoculum blanks (no test item),
- 4 test bottles (03590),
- 1 procedure control (sodium acetate) and
- 1 toxicity control (03590 plus sodium acetate).
Reference substance:
acetic acid, sodium salt
Test performance:
The relative biodegradation values calculated from the measurements performed during the test period revealed 57%, 75%, 64%, and 54% biodegradation of 03590, for vessel A, B, C and D, respectively (based on ThCO 2 ). Average biodegradation of the test item after 28 days is 63%.
Key result
Parameter:
% degradation (CO2 evolution)
Value:
>= 63 - <= 63
St. dev.:
8
Sampling time:
28 d
Remarks on result:
other: readily biodegradable
Validity criteria fulfilled:
yes
Interpretation of results:
readily biodegradable
Conclusions:
In conclusion, 03590 was designated as readily biodegradable.
Executive summary:

The relative biodegradation values calculated from the measurements performed during the test period revealed 57%, 75%, 64%, and 54% biodegradation of 03590, for vessel A, B, C and D, respectively (based on ThCO 2 ). Average biodegradation of the test item after 28 days is 63%. Since the test item consists of a mixture of structurally similar chemicals, the 10-day window need not be applied.

Description of key information

The study was performed in accordance with the OECD Principles of Good Laboratory Practice as accepted by Regulatory Authorities throughout the European Union.

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable
Type of water:
other: Mili-RO water

Additional information