Registration Dossier
Registration Dossier
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EC number: 203-298-2 | CAS number: 105-44-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-01-09 to 2018-01-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4-methylpentan-2-one oxime
- EC Number:
- 203-298-2
- EC Name:
- 4-methylpentan-2-one oxime
- Cas Number:
- 105-44-2
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 4-methylpentan-2-one oxime
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 2017 494
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.54
- Temp.:
- 20 °C
- pH:
- >= 7.62 - <= 8.43
Any other information on results incl. tables
Preliminary estimation:
| Solvent | Mass of sample (mg) | Solvent volume (mL) | Predicted solubility (g/L) | Log P | Analysis method |
| Water | 10000 | 1000 | 10.00 | 2.0 | Shake flask |
| Octanol | 1000 | 1 | 1000.00 | 2.0 | Shake flask |
Estimated logPow = 2.0
Regression outputs:
m= 6546173.0806
c= 21670.3333
r2= 0.9999
Main study:
Mean of 6 runs (1.5465, 1.5271, 1.5448, 1.5394, 1.5364, 1.5345).
Applicant's summary and conclusion
- Conclusions:
- The Log Pow of the test item was 1.54.
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