Registration Dossier
Registration Dossier
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EC number: 208-831-2 | CAS number: 542-85-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Methylisothiocyanate is an chemical analogue of ethylisothiocyanate.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Methylisothiocyanate - Acute oral toxicity
- Author:
- Lewis, R.J. Sr.
- Year:
- 2 004
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 2173
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Methyl isothiocyanate
- EC Number:
- 209-132-5
- EC Name:
- Methyl isothiocyanate
- Cas Number:
- 556-61-6
- Molecular formula:
- C2H3NS
- IUPAC Name:
- Methylisothiocyanate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 72 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- Ethylisothiocyanate is expected to be toxic based on the result of the analogue methylisothiocyanate.
- Executive summary:
Ethylisothiocyanate is expected to be toxic based on the result of the analogue methylisothiocyanate.
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